在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLCO2A1 Antibody, FITC conjugated

  • 中文名稱:
    SLCO2A1兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA856440LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SLCO2A1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SLCO2A1
  • 別名:
    SLCO2A1 antibody; OATP2A1 antibody; SLC21A2 antibody; Solute carrier organic anion transporter family member 2A1 antibody; Prostaglandin transporter antibody; PGT antibody; Solute carrier family 21 member 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Solute carrier organic anion transporter family member 2A1 protein (416-518AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Transports PGD2, as well as PGE1, PGE2 and PGF2A. Mediates the clearance of prostaglandins from the circulation through uptake across cell membrane which allows cytoplasmic oxidation and prostaglandin signal termination. May mediate the release of newly synthesized prostaglandins from cells and the transepithelial transport of prostaglandins (Probable).
  • 基因功能參考文獻:
    1. The findings reported here support causality of this SLCO2A1 mutation for autosomal recessive ICNC in this consanguineous Pakistani kindred. PMID: 27681482
    2. In Japanese patients with chronic nonspecific multiple ulcers of the small intestine, 2 of the 4 patients had mutation in the SLCO2A1 gene, became resistant to medical therapy, and underwent strictureplasty or ileal resection after long-term follow-up. PMID: 27467110
    3. in individuals carrying the SLCO2A1 A396T variant, the combination of thiazide-specific effects on free water generation and the increase in collecting duct water permeability from reduced SLCO2A1 activity combine to produce thiazide-induced hyponatremia PMID: 28783044
    4. A novel missense mutation c.101T > C in the SLCO2A1 gene causes pachydermoperiostosis of the complete type. PMID: 28602931
    5. Mutation analysis revealed a novel heterozygous mutation in the solute carrier organic anion transporter family member 2A1 gene at nucleotide 302 causing a substitution of the amino acid isoleucine to serine at codon 101 (p.IIe101Ser) in affected individuals. PMID: 27134495
    6. We herein report patients with pachydermoperiostosis (PDP)due to SLCO2A1 mutation in a Korean family. Similar to other East Asian populations, the SLCO2A1 gene may be a possible mutation spot of PDP in the Korean population. PMID: 25810087
    7. Data show that prostaglandin E3 (PGE3) uptake by prostaglandin transporter OATP2A1-expressing HEK293 cells (HEK/2A1) was the highest and followed by SLCO2B1 (HEK/1B1). PMID: 26692285
    8. In this article we describe a novel mutation in the SLCO2A1 causing Pachydermoperiostosis in a Lebanese family PMID: 25059581
    9. overexpression of SLCO2A1 could induce and knockdown inhibit the invasion of lung cancer cells. expression levels of p-mTOR, p-AKT and p-S6 were up-regulated or down-regulated with the overexpression or knockdown of SLCO2A1. PMID: 26464663
    10. cytoplasmic OATP2A1 likely facilitates prostaglandin E2 loading into suitable intracellular compartment(s) for efficient exocytotic prostaglandin E2 release from colorectal cancer cells exposed to oxidative stress PMID: 26850138
    11. findings indicate that loss-of-function mutations in the SLCO2A1 gene encoding a prostaglandin transporter cause the hereditary enteropathy CNSU PMID: 26539716
    12. SLCO2A1 and NOS3 are involved with prostaglandin reuptake/metabolism and nitric oxide production, respectively, and are consistently decreased in "non-Caucasian" fetal ductus arteriosus PMID: 26265282
    13. Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer. PMID: 25433169
    14. OATP2A1 also diminished the PGE2-mediated expression of interleukin-8 mRNA (IL-8) and hypoxia-inducible-factor 1alpha (HIF1alpha) protein in AGS-OATP2A1 cells. PMID: 25433165
    15. SLCO2A1 has a role in familial digital clubbing, colon neoplasia, and NSAID resistance PMID: 24838973
    16. a novel nonsense mutation p.E141* of the SLCO2A1 gene is associated with pachydermoperiostosis PMID: 24929850
    17. Three novel mutations within the SLCO2A1 gene have been demonstrated to be associated with Chinese primary hypertrophic osteoarthropathy patients. PMID: 24153155
    18. Identified two novel mutations in SLCO2A1. PMID: 24185079
    19. genetic association study in population in China: Nine different SLCO2A1 mutations were identified in subjects with primary hypertrophic osteoarthropathy (PHO) in 7 previously undescribed families; different homozygous mutations of SLCO2A1 cause PHO. PMID: 23509104
    20. Report SLCO2A1 is a novel gene responsible for pachydermoperiostosis in Japanese patients. PMID: 22906430
    21. Mutations in the prostaglandin transporter SLCO2A1 cause primary hypertrophic osteoarthropathy with digital clubbing. PMID: 22696055
    22. Prostaglandin transporter mutations cause pachydermoperiostosis with myelofibrosis. PMID: 22553128
    23. Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing. PMID: 22331663
    24. The findings confirmed that SLCO2A1 mutations inactivate prostaglandin E2 transport, and they indicated that mutations in SLCO2A1 are the pathogenic cause of primary hypertrophic osteoarthropathy. PMID: 22197487
    25. expression in fetal membranesfound primarily in the choriodecidua PMID: 20357271
    26. that PGT may play a role in transporting PGH(2) across cellular membranes. PMID: 20346915
    27. Human endometrial stromal cells treated with a combination of cAMP and medroxyprogesterone acetate to induce decidualization showed an increase in protein and mRNA levels. PMID: 16339169
    28. PGT level was significantly less in AD than in age-matched control brain homogenates. PMID: 18353443
    29. The existing model to explain increased PGE(2) in colorectal neoplasia should be modified to include the novel mechanism of coordinated up- and down-regulation of genes involved in PGE(2) transport. PMID: 19138942

    顯示更多

    收起更多

  • 相關疾病:
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Organo anion transporter (TC 2.A.60) family
  • 組織特異性:
    Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 10955

    OMIM: 601460

    KEGG: hsa:6578

    STRING: 9606.ENSP00000311291

    UniGene: Hs.518270



主站蜘蛛池模板: 久久无码国产专区精品| 爆乳高潮喷水无码正在播放 | 免费无码黄十八禁网站在线观看 | 在线亚洲精品国产成人av剧情| 亚洲精品美女久久久久久久| 五月av综合av国产av| 欧洲熟妇牲交| 七七久久成人影院网站| 丰满人妻被公侵犯完整版| 天天爽夜夜爽人人爽免费| 无码熟妇人妻av在线电影| 99久久久无码国产精品6| 成人3d动漫一区二区三区| 中文字幕精品视频在线看免费 | 欧美一区二区三区激情 | 果冻传媒一区二区天美传媒| 国产精品久久久久久不卡盗摄| 国产人妻精品一区二区三区不卡| 黄瓜视频在线观看| 丁香五月开心婷婷激情综合| 国产高清在线精品一区下载 | 99久热在线精品视频观看| 天堂mv在线mv免费mv香蕉| 亚洲国产一成人久久精品| 欧美黑人又粗又大久久久| 国产农村妇女精品一二区| 国产成人免费无码av在线播放| 午夜亚洲影院在线观看| 色噜噜狠狠狠狠色综合久一| 亚洲欧美综合区丁香五月小说 | 久久久久人妻一区精品色| 新狼窝色av性久久久久久| 亚洲旡码a∨一区二区三区| 亚洲精品高清国产一久久| 日韩精品一区二区午夜成人版| 日本老熟妇乱| 中字幕久久久人妻熟女天美传媒 | 综合无码精品人妻一区二区三区| 国产作爱视频免费播放| 欧美性猛交99久久久久99按摩| s级爆乳玩具酱国产vip皮裤|